This study was under taken to determine the chronic anti-inflammatory activity of Sandhi Abhay Tablet. Sandhi Abhay Tablet is an Ayurvedic proprietory formulation manufactured by SDM Pharmacy, Udupi, and Karnataka. Cotton pellet granuloma was produced by implantation of 100±1 mg of sterile cotton pellet both sides in the scapular region under ether anaesthesia in rat. Cotton pellet granuloma induced chronic inflammation was assessed by taking dried weight of granulation tissue, histopathological examination of adrenal gland, Serum Orosomucoid, Adrenal ascorbic acid and liver tissue biochemical parameters. Effect of Sandhi Abhay Tablet was assessed at two dose level in comparison to Dexomethasone (100μg/kg p.o.) as a reference standard drug. Therapeutically Equivalent Dose (TED) of Sandhi Abhay Tablet was (450mg/kg p.o.) and double to TED (TED × 2) was (900mg/kg p.o.). Dexomethasone produced significant decrease on body weight, granulation tissue formation and serum Orosomucoid and non-significant effect on adrenal ascorbic acid and other biochemical parameters of liver homogenate like Total Protein content, Lipid Peroxidation, Total glutathione and Glutathione peroxidase, Nitric oxide level and Catalase activity. Sandhi Abhay Tablet at both dose levels showed moderate effect on same and also non-significant effect on adrenal ascorbic acid and other biochemical parameters of liver tissue homogenate. Slight increase in cellularity of adrenal gland was observed in double to TED dose group, and in contrast decrease in cellularity was observed in Dexomethasone treated group. Based on data generated and histopathological profile, it is concluded that Sandhi Abhay Tablet at both dose levels showed moderate effect on chronic inflammation induced by Cotton pellet granuloma.
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